The article is devoted to the research and assessment of the development of the triple partnership between the participants

of innovation systems – universities, business, and government in the Latvia-Lithuania-Belarus cross-border region which consists of

Latvia’s regions (Latgale region), Lithuania’s regions (Vilnius region, Alytus region, Utena region, Panevezys region, Kaunas region),

Belarus’s regions (Vitebsk region, Grodno region, Minsk region, Mogilev region). The lack of attention to the above problems typical of

this cross-border region determined the relevance of the research. Innovations are one of the key factors both on the macro-level and on

the micro-level that influence the sustainable economic development of the region as well as the innovation potential of the enterprise.

The stable development and efficient function of the territorial innovation system is the main condition for this. The study is based on a

survey of 620 entrepreneurs from small and medium-sized businesses in the cross-border region.