In 2010s, the mainstream academic debate slowly but surely shifted towards European Union’s internal crisis and the possibility of its disintegration. United Kingdom applying to exit the Union in 2017 is the most recent and arguably the strongest indicator of such possibility. “Brexit” (as this process was dubbed) provides an interesting testing ground for latent European disintegration theories proposed by some political scientists. As the withdrawal negotiations have just started, one can only raise causal arguments for the future (if..., then); therefore this article employs scenario-building methodology recently established in political science with an aim to develop a set of scenarios of possible UK-EU relationship after Brexit. Four driving forces are cross-combined: (1) U.S. involvement in European security matters and bilateral relations with UK, (2) German leadership of the integrationist projects within the EU, (3) activism of the European Commission and the European Court of Justice, and (4) the stability of current minority cabinet in UK under Prime Minister May. The three scenarios that logically follow are: (1) UK as member of a nascent European security and defence union, (2) UK’s return to the EU, and (3) UK as an independent power in an “anglobal” world. Rarely, however, do any scenarios composed by political scientists ever materialize in full and a mix of all three scenarios is most likely to come to pass over the course of the next five years or so.